Fig. 5: Identification of MT inner surface binding PYG repeats in MIPs. | Nature Communications

Fig. 5: Identification of MT inner surface binding PYG repeats in MIPs.

From: Uncovering structural themes across cilia microtubule inner proteins with implications for human cilia function

Fig. 5

a Multiple sequence alignment of the PYG repeats in four human and three C. reinhardtii proteins identified by HMM-to-HMM searches. Only the outermost N-terminal PYG repeat unit for each protein is shown. Proteins are designated by their UniProt identifiers. Coloring schemes as per ClustalW parameters with modifications. b Module architecture of predicted PYG repeat proteins in human and C. reinhardtii. c PYG repeats of human FAM166B shown in the outer doublet lumen MT interface. d Structure of the PYG repeat in FAP252 where contacts between the MT lattice and the PYG repeat is shown for the conserved residues.

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