Fig. 1: Cryo-EM structures of the head region of ERGIC-53 in complex with MCFD2.
From: Structure of full-length ERGIC-53 in complex with MCFD2 for cargo transport
a Side and top views of the cryo-EM map of the head region of ERGIC-53 with MCFD2. Four ERGIC-53 protomers and four MCFD molecules are shown in magenta (ERGIC-53 protomer A), orange (protomer B), green (protomer C), cyan (protomer D), gray (MCFD2-A), yellow (MCFD2-B), pink (MCFD2-C), and slate blue (MCFD2-D), respectively. b Ribbon diagram of the structure of the tetrameric head region of the ERGIC-53. The four ERGIC-53 protomers and four MCFD2 molecules are shown in the same colors as in 1a. Green and cyan spheres represent calcium and zinc ions, respectively. c Details of the tetrameric head formation. The left two panels show structures of the head region of the ERGIC-53 protomers in the upper-CRD configuration (protomer A) and lower-CRD configuration (protomer B).
