Fig. 7: TET2 levels are negatively correlated with LEPTIN levels and BMI in humans.
From: A negative feedback loop between TET2 and leptin in adipocyte regulates body weight
a, b Genomic 5-hmC (a) and 5-mC (b) levels in SAT from the lean and obese humans (N = 3). c mRNA levels of TET2 and LEPTIN relative to ACTB in SAT (N = 8 nonobese and N = 7 obese subjects). d Correlation between TET2 and LEPTIN in SAT. e Correlation between TET2 and LEPTIN in adipocytes of SAT (Published microarray data: GSE44000). f TET2 levels in human SAT adipocytes were negatively associated with BMI (Published microarray data: GSE44000). g Leptin secretion in adipocytes from lean SAT treated with DMSO or Bobcat339 for 24 h (N = 3). h Model of the negative feedback loop between TET2 and leptin in adipocytes. All data are presented as mean ± SEM. N indicates the number of biologically independent samples examined. P-values are indicated on the graph. Statistical values are determined by two-sided unpaired Student’s t-test in (a–c) and (g), two-sided Spearman’s correlation analysis in (d–f). Source data are provided as a Source Data File.
