Table 1 Assignment of each cynomolgus macaque to low dose (1 infected mosquito) or high dose (10 infected mosquitoes) of DENV, or high dose (15 infected mosquitoes) of ZIKV, or control (10 uninfected mosquitoes) treatments and subsequent viremia, transmission to mosquitoes, and neutralizing antibody response
From: Trade-offs shaping transmission of sylvatic dengue and Zika viruses in monkey hosts
NHP ID | Sex | A priori Virus treatment | Post hoc Virus Treatmenta | No. infected mosquitoes engorged | No. infected mosquitoes with detectable virus in saliva post passageb; (total dose virus delivered (log10 pfu))c | Days on which virus was detectable in serum, day of peak titer (peak titer log10pfu/ ml) | Days on which virus was transmitted to mosquitoes (% infectedd) | PRNT80 on Day | |
|---|---|---|---|---|---|---|---|---|---|
−10 | 28 | ||||||||
NV289 | M | Control | Control | 8 | 0 | – | – | <20 | <20 |
UG171 | F | Control | Control | 5 | 0 | – | – | <20 | <20 |
NV259 | F | Control | Control | 9 | 0 | – | – | <20 | <20 |
SB393 | M | Low Dose DENV | Low Dose DENV | 1 | 0 | – | – | <20 | 40 |
FR469A | M | Low Dose DENV | Low Dose DENV | 1 | 1 | 4 (3.9) | – | <20 | 160 |
UG253Aa | M | Low Dose DENV | Control | 1 | 0 | – | – | <20 | <20 |
BC407 | F | Low Dose DENV | Low Dose DENV | 1 | 1 | – | – | <20 | <20 |
CP60 | F | Low Dose DENV | Low Dose DENV | 1 | 1 | – | – | <20 | 80 |
BC116A | M | High Dose DENV | High Dose DENV | 7 | 6 | 4 (nae) | – | <20 | 40 |
FR423A | M | High Dose DENV | High Dose DENV | 8 | 5 | 4, 7 (2.5) | 5 (60%) | <20 | 320 |
SB395 | F | High Dose DENV | High Dose DENV | 8 | 3 | – | – | <20 | 1280 |
FR840 | F | High Dose DENV | High Dose DENV | 9 | 4 | – | 8 (100%) | <20 | 320 |
BC167 | F | High Dose DENV | High Dose DENV | 7 | 3 | – | 5 (20%) | <20 | 1280 |
UGZ626 | F | High Dose ZIKV | High Dose ZIKV | 7 | 7 (4.41) | 2, 3, 4, 5 (5.0) | 2 (40%) 3 (54%) 4 (89%) 5 (70%) | <20 | >640 |
EC644 | M | High Dose ZIKV | High Dose ZIKV | 11 | 9 (4.48) | 3, 4, 5 (5.3) | 3 (30%) 4 (100%) 5 (100%) | <20 | 160 |
FR1221 | F | High Dose ZIKV | High Dose ZIKV | 7 | 5(4.42) | 3, 4, 5 (4.7) | 3 (9%) 4 (81%) 5 (100%) | <20 | 40 |
