Fig. 3: Comparing properties of single-modality and cross-modality lead SNPs and genes.
a Gene-ontology biological processes, molecular functions and cellular components that were (Bonferroni-corrected) significantly enriched for cross-modality, sMRI-modality and/or dMRI-modality genes (none of the GO terms tested showed enrichment for the 6 fMRI-modality genes). Node size reflects gene-set size, edges reflect pathway similarity scores (Methods). b Functional consequences of single-modality and cross-modality lead SNPs as annotated with ANNOVAR34. When the null hypothesis (OR = 1) could be rejected after Bonferroni correction (p < 1.14 × 10−3), the solid line indicates significant enrichment of the annotation. Annotations of 43,492 (unique) lead SNPs derived from 558 traits across 24 trait domains from Watanabe et al. were used as reference for Fisher Exact Test (Supplementary Data 9). ncRNA non-coding RNA, UTR untranslated region. c Mean-normalized expression (y-axis) of cross-modality and single-modality genes over developmental timepoints (x-axis; log10 scale). Gray shading indicates 95% confidence intervals. The mean-normalized expression of fMRI-modality genes is displayed in Supplementary Fig. 8, since the number of genes (n = 5) was low and therefore created an unreliable pattern. d Cell-type enrichment analysis with Fisher Exact test for fetal brain tissue from Bhaduri et al.40. Bonferroni corrected significant results (p < (0.05/30 = ) 1.67 × 10−3) are indicated by an asterisk (*). OR odds ratio, ipc intermediate progenitor cells, oligo oligodendrocytes.
