Fig. 2: Forrest plot for the associations of 40 protein and cancer risk and pan-cancer risk forrest plots for PLAUR and CTRB1.
From: Identifying therapeutic targets for cancer among 2074 circulating proteins and risk of nine cancers
Proteins associated with cancer risk (A) after correction for multiple testing for the number of proteins analysed in this study per-cancer. Odds ratio estimates are estimated using Wald ratios scaled per standard deviation increment in relative circulating protein concentrations. Confidence intervals (95% CI) are derived using the standard Wald ratio formula and reflect the precision of the cis-pQTL estimate in cancer GWAS scaled by the beta for the cis-pQTL association with protein concentrations. Sample sizes for cancer GWAS can be found in methods. Association of higher PLAUR with cancer risk (B) coloured by the colocalization probability (PP4), where MR Wald p < 0.05. Association for higher CTRB1 with cancer risk presented to demonstrate pancreas-specific association (C) with colour scheme as described above. All tests are two-sided.
