Fig. 1: The overall structures of H4R/Gi complexes.
From: Structural basis of ligand recognition and design of antihistamines targeting histamine H4 receptor
a–d Histamine-bound H4R/Gi, Clobenpropit-bound H4R/Gi, VUF6884-bound H4R/Gi, and Clozapine-bound H4R/Gi, respectively. Left panel, orthogonal views of the cryo-EM density map; right panel, model of the complex in the same view and color scheme as shown in the left panel. Ligands, histamine, Clobenpropit, VUF6884, and Clozapine were shown in a stick model with a density map (contour level of 0.4 in chimera) and in actual chemical structure in the middle of each sub-figure.
