Fig. 3: Non-histamine agonists recognition and binding of H4R.
From: Structural basis of ligand recognition and design of antihistamines targeting histamine H4 receptor
a The ligand binding pocket of Clobenpropit, VUF6884, and Clozapine. b A schematic map of Clobenpropit, VUF6884, and Clozapine/receptor interaction. Green color, hydrophobic interaction; purple color, polar interaction. c pKi of Clobenpropit, VUF6884 and Clozapine binding of H4R mutants. d pEC50 of Gi activation of H4R mutants by Clobenpropit, VUF6884 and Clozapine. The green bars indicate agonist and the red bars indicate inverse agonist. From c, d, data are presented as mean values ± SEM.; n = 3–4 independent experiments for c and n = 3–7 independent experiments for d. Each point in the figure represents an independent experiment. Source data are provided as a Source Data file.
