Fig. 5: Antihistamine design of H4R.
From: Structural basis of ligand recognition and design of antihistamines targeting histamine H4 receptor
a A schematic diagram of the antihistamine design of H4R, utilizing key information of E182/ligand interaction. b VUF5202 exhibits inverse agonist activity. Data are presented as mean values ± SEM.; n = 3 independent experiments for the binding assay (both Clobenpropit and VUF5202), n = 6 for Clobenpropit BRET assay, and n = 3 for VUF5202 BRET assay. Source data are provided as a Source Data file.
