Fig. 3: Synthesis of chiral bicyclo[2.2.2]octane 11.
Reagents and conditions: a TfOH (2.2 equiv), 2,6-lutidine (2.4 equiv), DCM, ‒78 to 0 °C, then 14, 91%; b Cu(OTf)2 (0.1 equiv), L1 (0.11 equiv), DCM, 50 °C, 96% yield, 92% ee. TfOH triflic acid, 2,6-lutidine 2,6-dimethylpyridine, DCM dichloromethane.
