Fig. 7: A model for MoNLE1 disturbing OsPUX8B.2 function.
From: A fungal core effector exploits the OsPUX8B.2–OsCDC48-6 module to suppress plant immunity
a Upon M. oryzae infection, the expression of OsPUX8B.2, OsCDC48-6, and OsBHT is induced. OsBHT negatively regulates rice defense against M. oryzae infection, while the OsPUX8B.2–OsCDC48-6 module promotes degradation of OsBHT to maintain a proper immune level in plants. b M. oryzae has evolved the conserved core nuclear effector MoNLE1 to counteract the role of OsPUX8B.2–OsCDC48-6 in regulating host immunity. First, MoNLE1 directly binds to OsPUXB.2 and promotes its migration to the nucleus; second, binding of MoNLE1 to OsPUX8B.2 facilitates the association of OsPUX8B.2 with OsCDC48-6 and stimulates the degradation of OsPUXB.2 and MoNLE1 in rice nuclei; third, MoNLE1 disrupts the connection between OsPUX8B.2 and OsBHT, which may help stabilize OsBHT and thus support a successful invasion of M. oryzae.
