Fig. 2: Flexible binding of the Bre1 complex revealed by the 3DFlex analysis.
From: Structure of the human Bre1 complex bound to the nucleosome
a Distribution of the latent coordinates. Coordinates that correspond to the structures shown in (b–e) are indicated. Green and orange circles represent the volume series shown in Supplementary Movies 2 and 3, respectively. b–e Conformational changes represented by the first (b, c) and second (d, e) dimensions. b, d An overall view. c, e A close-up view. f Residues whose modifications or substitutions (H2BS112GlcNAc, H3K36M, H3K37ac, H3Y41ph, H3R42A, H3K56ac, and H3R42me2a) upregulate Bre1 activity. H2BK120 itself is also shown.
