Fig. 4: Estimated average treatment effect (ATE) for disease-free survival (DFS) for the 113 medications passing the adjustment quality test.
From: Concomitant medication, comorbidity and survival in patients with breast cancer
Medications are represented by circles color-coded by ATC level and linked to the full name of the medication. The ATE (i.e. the Cox hazard ratio, HR) is plotted on the x-axis. Lower HRs (protective effect of the medication, increasing disease-free survival in breast cancer) are displayed on the left. Higher HRs (deleterious effect of the medication, decreasing disease-free survival in breast cancer) are displayed on the right. An HR of 1 (no effect of the medication on disease-free survival in breast cancer) is indicated by a vertical line. We used two-sided Wald tests with robust covariances for statistical inference. No adjustment for multiple comparisons was made at this stage of the pipeline. Statistical significance is plotted on the y-axis. Lower p-values (high statistical significance) are displayed at the top. Higher p-values (low statistical significance) are displayed at the bottom. An interactive display is available via the ADRENALINE web application (https://adrenaline.curie.fr/survival_analysis). Source data are provided as a Source Data file. Abbreviations: ATE: average treatment effect; ATC: Anatomical Therapeutic Chemical.
