Fig. 6: Mediation analyzes for the 23 medications with a significant protective or deleterious effect for disease-free survival (DFS).
From: Concomitant medication, comorbidity and survival in patients with breast cancer
Medications are grouped and color-coded by ATC level. Significant protective associations are shown in blue. Significant deleterious associations are shown in red. Non-significant associations are shown in white. (A) Average treatment effect (ATE) of the medication (Cox hazard ratio, HR). (B) Breakdown of the ATE into three path-specific effects (expressed as percentages): direct path, subtype path, and node path. Source data are provided as a Source Data file. ATE average treatment effect, ATC Anatomical Therapeutic Chemical, HR hazard ratio, A* alimentary tract and metabolism, B** blood and blood-forming organs, H*** systemic hormonal preparations, excluding sex hormones and insulins, R**** respiratory system.
