Fig. 8: CREBBP and KMT2D deficiency suppresses a core immune signature in GC B cells that is retained and shared between murine and human lymphomas. | Nature Communications

Fig. 8: CREBBP and KMT2D deficiency suppresses a core immune signature in GC B cells that is retained and shared between murine and human lymphomas.

From: Loss of CREBBP and KMT2D cooperate to accelerate lymphomagenesis and shape the lymphoma immune microenvironment

Fig. 8

a GSVA analysis using genes downregulated in BCL2 + CK vs BCL2 murine lymphoma cells at day 235 as gene set against human FL RNA-seq datasets (epiWT/C/K/CK: n = 16/10/8/15 patients). The p values were calculated using two-tailed Wilcoxon rank sum test. b Heatmap showing the relative expression levels of CK_consistent_down_genes (n = 196), including genes exhibiting downregulation in at least two of the indicated RNA-seq datasets. c Functional annotation of CK_consistent_down_genes by Enrichr and Toppgene.

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