Fig. 8: Working model by which condensin complexes regulate brain development in Drosophila.

Condensin I and II restrict RTE expression and retrotransposition in neuroblasts and intermediate neural precursor cells in the developing larval brain. This, in turn, restricts cell death of stem and precursor cells, as well as cells adjacent to stem/precursor cells, thereby allowing the brain to achieve proper volume by the late pupal stages.