Fig. 2: Structures of the α- and β-subunits.
From: Architecture and activation of human muscle phosphorylase kinase
a Schematic representations of the α- and β-subunits. b Structure of the α-subunit. The D1–D5 domains, as well as the N- and C-termini, are indicated. c Structure of the β-subunit. d Structural overlay of the D1 domain of the α-subunit and a glycosidase (PDB ID: 5Z3F), shown in yellow and green, respectively. e Neither the αγδ subcomplex nor the PhK holoenzyme has detectable glucoamylase activity against maltose, isomaltose, or glycogen. The human lysosomal α-glucosidase (GAA) is used as a positive control. All data points, as well as the mean ± s.d., are shown. n = 3 biological replicates.
