Fig. 2: Off-target interaction of ESK1 with common HLAp sequences in primary liver tissue.
From: The physiological interactome of TCR-like antibody therapeutics in human tissues
A Volcano plots showing significant (one-factor ANOVA, -log10(p)≥1.5) enrichment of peptides for ESK1 and MAGE-A4 in liver tissue (all peptides, left panel; peptides predicted to bind to HLA-A*02:01, right panel). B Sequence motif of the ESK1-enriched peptides that are predicted to bind to HLA-A*02:01. Shown is the frequency (probability) of each amino acid in each position across the peptide sequence from N- to C-terminus (left to right, positions 1-9). C Sequence motifs from Gejman et al. (left panel) and our study (right panel). D Venn diagram depicting the lack of overlap of peptide sequences shortlisted by Gejman et al. and our study as Esk1 binders.
