Table 2 Change of the solvent-accessible surface area (ΔSASA) of the RMFPNAPYL peptide in the absence of the ESK1 Fab (calculated from the X-ray crystal structure with PDB ID 4WUU) and comparison to the confirmed cross-reactive peptides, ordered by their signal in the JNFAT activation assay

From: The physiological interactome of TCR-like antibody therapeutics in human tissues

Position

1

2

3

4

5

6

7

8

9

WT1126-134

R

M

F

P

N

A

P

Y

L

ΔSASA without ESK1

69.1

0.0

0.0

35.7

15.1

0.0

0.0

0.0

0.0

Interacts with ESK1

✔

⨯

⨯

(✔)

⨯

⨯

⨯

⨯

⨯

SHC1469-477

R

V

P

P

P

P

Q

S

V

ARHGEF26863-871

R

L

L

G

L

E

T

N

V

RBM4B59-67

K

L

H

G

V

N

I

N

V

USP9Y1674-1682

R

L

W

G

E

P

V

N

L

CYP2C859-67

K

V

Y

G

P

V

F

T

V

CRYL1130-138

K

L

F

A

G

L

V

H

V

SF3B478-86

K

L

Y

G

K

P

I

R

V

ILF2127-135

K

I

L

P

T

L

E

A

V

  1. Bold font: Amino acid identical to respective residue in RMFPNAPYL peptide.
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