Fig. 1: Profiling of glycomic alterations in ovarian tumors under immune pressures.

a Schematic representation of experimental design examining the impact of immune pressures on ovarian cancer cell surface glycosylation. Components of the graphic were created with BioRender.com. b Heatmap depicting the levels of specific glycan structures in tumors grown in immunocompetent (C57BL/6; B6) or immunocompromised (NSG) environments. In vitro cancer cells were used to represent basal glycosylation. Red represents higher expression, while blue represents lower expression. n = 3 mice. P-values and False Discovery Rates (FDR) for the comparisons were estimated using R package limma v.3.46.0. c Schematic representation of experimental design examining the differences between HR-proficient and HR-deficient ovarian tumors grown in B6 mice. Components of the graphic were created with BioRender.com. d Heatmap depicting the levels of specific glycan structures in HR-proficient vs HR-deficient tumors grown in immunocompetent B6 mice. In vitro cancer cells were used to represent basal glycosylation. Red represents higher expression, while blue represents lower expression. n = 3 mice. P-values and False Discovery Rates (FDR) for the comparisons were estimated using R package limma v.3.46.0.