Fig. 8: Antitumor efficacy of intravenously injected FP NPs in H1975-luc and A549-luc orthotopic lung tumors. | Nature Communications

Fig. 8: Antitumor efficacy of intravenously injected FP NPs in H1975-luc and A549-luc orthotopic lung tumors.

From: Nanoparticles targeting mutant p53 overcome chemoresistance and tumor recurrence in non-small cell lung cancer

Fig. 8

a, g Schematic illustration of the experimental design. b, h The progression of orthotopic lung tumors (n = 5 mice per group) in BALB/c nude mice. A representative bioluminescent image from each group is shown. c, i The final anatomical picture and H&E staining of the lungs. Scale bars, 5 mm. d, j Average tumor nodule. Tumor nodules of 2–10 mm3 in volume were counted using harvested lungs from the control and treated groups, and the average number of tumor nodules was determined. Each dot represents a tumor from an individual mouse. The tumor nodules in the lungs are indicated by arrows (one-way ANOVA followed by Tukey’s HSD post hoc test). e, k Quantitative bioluminescence analysis in mice bearing orthotopic lung tumors; P/S = photons/second (two-way ANOVA followed by Tukey’s multiple comparisons post test). f, l Mouse body weight in the orthotopic lung tumor mouse model (two-way ANOVA followed by Tukey’s multiple comparisons post test). Data are shown as the mean ± SD; n.s. no significance. Source data are provided as a Source Data file.

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