Fig. 2: Molecular mapping of pathogenic mutations.
From: Structural bases of inhibitory mechanism of CaV1.2 channel inhibitors
a–f Disease related mutations are located on DI (b), DII (c), DIII (d), DIV (e), and CTD (f). DI, DII, DIII, DIV, and CTD of α1 subunit are colored in deep green, light green, deep blue, mauve, and orange, respectively. Subunits α2, δ1, and β2b are colored in turquoise, pink, and magenta, respectively. Mutation sites are marked with spheres and colored in blue (gain of function), yellow (loss of function), and red (other), respectively.
