Fig. 6: Representation of ion/ATP conducting pathway in PANX1 and PANX3.
From: Cryo-EM structures of pannexin 1 and 3 reveal differences among pannexin isoforms
The minimum radius is observed at the first constriction in PANX isoforms. a The minimum radius is 4.8 Å for PANX3 at the constriction formed by I74. b The PANX1WT has a minimum radius of 4.2 Å formed by W74. c The constriction point is created by W74 in PANX1R217H. The constriction point is 2.4 Å in PANX1R217H. d 2D representation of the hole profile. The line represents the minimum radius for PANX1WT at 4.2 Å formed by the first constriction (W74) in PANX1 channels.
