Fig. 2: Adjusted hazard ratio by HDL-C change in two models.

a Cancer risk by high density lipoprotein cholesterol (HDL-C) change after excluding any cancer developed within 1 years from first measurement of HDL-C (model I). b Cancer risk after excluding any cancer developed within 2 years from first measurement of HDL-C (model II). c Cancer risk after excluding any cancer developed up to second measurement of HDL-C (model III). X-axis is adjusted hazard ratio (aHR) and y-axis is HDL-C change group. Adjusted HRs and CIs are derived from Cox proportional regression analysis. The dashed blue lines illustrate an HR of 1. The reference is a persistently normal (Normal-to-Normal) group. The HR is indicated with the central bar and the error bars show the 95% confidence interval (CI). Red bar is statistical significant HR with CI. Low to Low (n = 392,532), Low to Normal (n = 326,402), Normal to Low (n = 385,774), Normal to Normal (n = 2,026,087) in model I. Low to Low (n = 389,731), Low to Normal (n = 324,102), Normal to Low (n = 382,820), Normal to Normal (n = 2,013,369) in model II. Low to Low (n = 380,934), Low to Normal (n = 698,472), Normal to Low (n = 373,488), Normal to Normal (n = 1,975,069) in model IIII. The exact hazard ratios and 95% confidence intervals are provided in Table 2 and Supplementary Tables 3, 4.