Fig. 2: Prognostic evaluation of the optimal polygenic prognostic score (i.e., PPS287) in the ZJCRC and PLCO cohorts. | Nature Communications

Fig. 2: Prognostic evaluation of the optimal polygenic prognostic score (i.e., PPS287) in the ZJCRC and PLCO cohorts.

From: Integration of pathologic characteristics, genetic risk and lifestyle exposure for colorectal cancer survival assessment

Fig. 2

A Kaplan–Meier curves for overall survival probability stratified by different levels of PPS (based on median value) in the ZJCRC and PLCO cohorts. B Calibration curve of different prognostic models for predicting 5-year survival probability in the ZJCRC and PLCO cohorts. The vertical error bars denote the 95% CI. C Time-dependent ROC curves of different prognostic models regarding 5-year survival probability in the ZJCRC and PLCO cohorts. The traditional model included sex, age, smoking status and drinking status for the ZJCRC cohort; and sex, age, smoking status, drinking status, stage and grade for the PLCO cohort. The combined model included both traditional factors and PPS. The sample sizes of ZJCRC and PLCO cohorts are 543 and 713 cases. Note: PLCO Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial, PPS polygenic prognostic score, ROC receiver operating characteristics, AUC area under the curve, 95% CI 95% confidence interval.

Back to article page