Table 1 Basic characteristics of study subjects
Variable | Derivation stage | Validation stage | Testing stage | ||
|---|---|---|---|---|---|
NJCRC | UK Biobank | TCGA | ZJCRC | PLCO | |
Patients, N | 1082 | 2621 | 470 | 543 | 713 |
Ancestrya | EAS | EUR | EUR | EAS | EUR |
Median follow-up time (months) | 51.7 | 48.6 | 23.4 | 74.7 | 48.2 |
Death, N (%) | |||||
Yes | 340 (31.4%) | 779 (29.7%) | 100 (21.3%) | 152 (28.0%) | 177 (24.8%) |
No | 742 (68.6%) | 1842 (70.3%) | 370 (78.7%) | 391 (72.0%) | 536 (75.2%) |
Sex, N (%) | |||||
Male | 647 (59.8%) | 1555 (59.3%) | 248 (52.8%) | 289 (53.2%) | 419 (58.8%) |
Female | 435 (40.2%) | 1066 (40.7%) | 222 (47.2%) | 254 (46.8%) | 294 (41.2%) |
Age (year), mean ± SD | 58.3 ± 12.7 | 65.2 ± 6.5 | 67.3 ± 12.5 | 63.5 ± 10.8 | 70.1 ± 6.6 |
Smoking status, N (%) | |||||
Ever | 303 (28.3%) | 1412 (54.0%) | – | 185 (34.2%) | 402 (56.4%) |
Never | 768 (71.7%) | 1203 (46.0%) | – | 356 (65.8%) | 311 (43.6%) |
Missing | 11 | 6 | 470 | 2 | 0 |
Drinking status, N (%) | |||||
Ever | 258 (24.2%) | 2539 (97.0%) | – | 137 (25.4%) | 577 (91.7%) |
Never | 810 (75.8%) | 78 (3.0%) | – | 403 (74.6%) | 52 (8.3%) |
Missing | 14 | 4 | 470 | 3 | 84 |
Stageb, N (%) | |||||
1 | 34 (3.2%) | – | 83 (18.4%) | – | 270 (38.2%) |
2 | 332 (31.1%) | – | 170 (37.7%) | – | 195 (27.6%) |
3 | 387 (36.2%) | – | 131 (29.0%) | – | 154 (21.8%) |
4 | 315 (29.5%) | – | 67 (14.9%) | – | 87 (12.3%) |
Missing | 14 | 2621 | 19 | 543 | 7 |
Gradec, N (%) | |||||
G1 | 38 (3.6%) | – | – | – | 63 (9.5%) |
G2 | 785 (74.5%) | – | – | – | 471 (71.1%) |
G3 | 230 (21.8%) | – | – | – | 119 (18%) |
G4 | 0 | – | – | – | 9 (1.4%) |
Missing | 29 | 2621 | 470 | 543 | 51 |
