Table 3 The association of pathologic stage or grade, genetic risk and healthy lifestyle with overall survival of colorectal cancer patients in the PLCO cohort

Stage/grade	Genetic risk	Lifestyle	Deaths/All^a	OS^b	3-year OS^b	5-year OS^b	HR (95% CI)^c	P^c
Low	Low	Favorable	4/110	92.90%	99.08%	99.08%	0.17 (0.03, 0.94)	0.042
		Unfavorable	7/58	65.78%	96.43%	96.43%	1.00 (reference)
	High	Favorable	19/103	68.16%	91.66%	84.42%	0.51 (0.21, 1.21)	0.124
		Unfavorable	12/57	66.12%	89.75%	82.25%	1.00 (reference)
High	Low	Favorable	28/82	54.69%	70.26%	59.24%	0.95 (0.38, 2.33)	0.904
		Unfavorable	11/36	65.21%	73.19%	65.21%	1.00 (reference)
	High	Favorable	44/98	31.85%	65.30%	49.52%	0.78 (0.40, 1.54)	0.477
		Unfavorable	19/33	31.42%	58.04%	41.90%	1.00 (reference)

PLCO Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial, HR hazard ratio, 95% CI 95% confidence interval.
^aNumber of deaths/number of all cases.
^bOS, overall survival probability.
^cDerived from the Cox regression model with the adjustment of sex, age, research center, arm and top 10 principal components. The P value is two-sided.

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