Fig. 8: A model to explain how Aβ-LTMRs function in both transmitting and alleviating mechanic hyperalgesia. | Nature Communications

Fig. 8: A model to explain how Aβ-LTMRs function in both transmitting and alleviating mechanic hyperalgesia.

From: Distinct local and global functions of mouse Aβ low-threshold mechanoreceptors in mechanical nociception

Fig. 8

Illustration shows anatomy of central projections of nociceptors and Aβ-LTMRs and the inter-modal and inter-somatotopic crosstalk. Central terminals of nociceptors only innervate one or two spinal cord segments, whereas Aβ-LTMRs have ascending and descending axons projecting through the dorsal column and 3rd order collaterals covering the dorsal horn of 6 to 8 spinal cord segments. This anatomical feature allows an Aβ-LTMR to interact with nociceptors and other Aβ-LTMRs in 3 to 4 dermatomes away.

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