Fig. 3: Variations in HGSOC molecular subtype signatures.
a Distribution of Module scores for the four molecular subtype signatures in each of the CNA-based clusters in patient 5. b Spatial distribution of Module scores for the four molecular subtype signatures in patient 5. c Distribution of Module scores for the four molecular subtype signatures in each of the CNA-based clusters in patient 1. d Spatial distribution of Module scores for the four molecular subtype signatures in patient 1. The labels shown correspond to the mesenchymal (C1.MES), immunoreactive (C2.IMM), differentiated (C4.DIF), and proliferative (C5.PRO) subtypes respectively; IMM and DIF are associated with good outcomes while MES and PRO are associated with poor outcomes25. For (a) and (c), black lines are medians, red dotted lines show the value if all spots are combined as a pseudo-bulk. ns and bars indicate seven pairs of clusters where there was no significant difference in the module score; all other pairwise comparisons returned significant results, significance was determined using two-sided Mann-Whitney U test with Benjamini-Hochberg correction and 0.05 threshold. Source Data for panels (a) and (c) are provided.
