Fig. 3: Spatial transcriptomics analysis of tumor #3133 T.

a Hematoxylin and eosin (H&E) staining in the formalin-fixed paraffin-embedded (FFPE) section of one tumor (#3133 T). The two annotated regions correspond to embryonal nodules surrounded by fetal areas. b Ternary graph showing the deconvoluted proportions of epithelial HB cell states in each Visium spot of regions 1 (left) and 2 (right). Visium spots were annotated by a pathologist and are colored by histology. c Focus on region 1 of the FFPE slide with a nodule of embryonal cells surrounded by fetal cells. d Spatial distribution of the mean expression of scH and scLP markers (Supplementary Data 3) in region 1. e Anti-correlation of scH and scLP markers across Visium spots in region 1, colored according to their histological annotation in (c). f Focus on region 2 of the FFPE slide, with spots annotated by histology. g Spatial distribution of the mean expression of scH and scLP markers in region 2. h Anti-correlation of scH and scLP markers across Visium spots in region 2, colored according to their histological annotation in panel f. Source data are provided in the Source Data file.