Fig. 6: Progressive activation of transcription factors along the scLP-scH differentiation axis. | Nature Communications

Fig. 6: Progressive activation of transcription factors along the scLP-scH differentiation axis.

From: Single-cell multiomics reveals the interplay of clonal evolution and cellular plasticity in hepatoblastoma

Fig. 6

Heatmaps showing the single-nucleus expression of transcription factors (TF, left), the average expression of their target genes (middle) and their motif deviations from snATAC-seq (right) along the scLP-scH axis. ScH, scH/LP and scLP cells (in columns) were ordered in each panel according to snRNA-seq PC2. TFs (in rows) were ordered according to their peak of activation along PC2. Cells are annotated by sample of origin and single-cell state. TFs are annotated according to the gene regulatory network they belong to (Fig. 5a).

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