Fig. 7: Deconvolution of hepatoblastoma cell states in 100 bulk RNA-seq profiles. | Nature Communications

Fig. 7: Deconvolution of hepatoblastoma cell states in 100 bulk RNA-seq profiles.

From: Single-cell multiomics reveals the interplay of clonal evolution and cellular plasticity in hepatoblastoma

Fig. 7

a Comparison of cell proportions identified in single-nucleus data or our 6 HB samples (left) and those estimated by Bisque deconvolution tool in matched bulk RNA-seq profiles (right). b Deconvolution of HB cell states from bulk RNA-seq profiles of 100 HB samples (Hirsch data set5). Two barplots indicate the % of stromal cells (top) and tumor cell states (middle) in each sample. Bulk transcriptomic subgroups and histological components identified in mirror blocks are annotated below. c Correlation (Pearson’s correlation test, two-sided) between the proportions of scH, scLP and scM cells estimated by Bisque and the expression of their gene regulatory networks (GRNs). Source data are provided in the Source Data file.

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