Fig. 7: A revised and expanded model for UHRF1 functions in DNA methylation homeostasis.
From: Non-canonical functions of UHRF1 maintain DNA methylation homeostasis in cancer cells
Left panel: the canonical function of UHRF1 is to promote DNA methylation maintenance by DNMT1. Right panel: we demonstrate non-canonical functions of UHRF1 that are independent of DNMT1 but contribute to DNA methylation homeostasis.
