Fig. 1: Cryo-EM structure of the SV2A–BoNT/A2 HC complex bound to LEV.
From: Structural basis for antiepileptic drugs and botulinum neurotoxin recognition of SV2A
a Cryo-EM map of the SV2A–BoNT/A2 HC complex bound to LEV. The globally refined map of the SV2A–HCA2–LEV complex and the local refinement map of the LD4A–HCA2 complex are combined. The N- and C-terminal halves of the SV2A TMD are colored in pale and forest green, respectively. LD4A is colored in deep teal, and HCA2 is colored in orange. A micelle-like density (gray) surrounds SV2A TMD. b Ribbon representation of the SV2A–HCA2–LEV complex. The coloring scheme is the same as that in (a). c SV2A structure in different colors for each secondary-structure element. d Topology diagram of SV2A. The beginning and end of each secondary-structure element are numbered. The coloring scheme is the same as that in (c).
