Fig. 2: Interaction between SV2A and BoNT.
From: Structural basis for antiepileptic drugs and botulinum neurotoxin recognition of SV2A
a The structure of the LD4A–HCA2 interaction. b The protein–protein interaction between HCA2 and LD4A. The interacting residues are shown as sticks, and the hydrogen bonds are shown as dashed lines. c Cryo-EM map of the binding interface between LD4A and HCA2. d The protein–glycan interaction between HCA2 and LD4A. HCA2 recognizes the N-glycans attached to SV2A Asn573. e Superposition of HCA2–GD1a complex (PDBID = 7Z5S) onto the SV2A–HCA2–LEV complex. f Model of the full-length BoNT/A1 bound to SV2A. g Model of the full-length BoNT/E bound to SV2A as a dual-receptor complex.
