Fig. 4: Brivaracetam binding site.
From: Structural basis for antiepileptic drugs and botulinum neurotoxin recognition of SV2A
a Close-up view of the BRV binding site. The residues interacting with BRV are indicated by sticks. The cryo-EM density of the bound BRV is shown in blue mesh. b Label-free spectral shift assay. Ratios of the SV2A intrinsic tryptophan fluorescence at 350 nm/330 nm with a given concentration of BRV are plotted. Prots (black) show the mean derived from n = 3 technical replicates (red, orange, and purple circles) and the error bars show the standard deviations. Source data are provided as a Source Data file.
