Table 2 Effect of RIKEN NPDs on the enzymatic activity of ETC complexes
From: Identification of a family of species-selective complex I inhibitors as potential anthelmintics
% Activity | |||||
|---|---|---|---|---|---|
Compound ID | Structural Group | Complex I | Complex II | Complex III | Complex IV |
Rotenone | Control | 0.00 (0.0) | 105.97 (3.17) | 99.20 (1.32) | 99.57 (1.12) |
Wact-11 | Control | 84.83 (1.45) | 24.43 (0.62) | 90.97 (1.75) | 89.00 (0.63) |
Antimycin A | Control | 117.05 (0.43) | 79.54 (5.98) | 0.00 (0.0) | 94.00 (1.10) |
KCN | Control | 128.00 (1.32) | 104.53 (5.34) | 104.75 (2.82) | 0.40 (0.20) |
NPD8902 | 1 | 27.82 (0.70) | 117.39 (3.63) | 74.47 (2.75) | 0.84 (0.45) |
NPD6380 | 2 | 86.43 (2.27) | 102.27 (2.46) | 107.06 (1.36) | 115.38 (4.42) |
NPD8034 | 2 | 99.30 (2.57) | 89.02 (4.77) | 95.08 (1.51) | 96.04 (2.78) |
NPD1450 | 2 | 84.47 (2.03) | 103.01 (4.34) | 111.72 (0.94) | 117.12 (3.30) |
NPD8366 | 3 | 102.66 (1.57) | 86.41 (3.37) | 76.74 (1.10) | 97.72 (2.77) |
NPD8298 | 3 | 79.90 (1.23) | 110.37 (5.08) | 101.94 (2.48) | 108.05 (2.17) |
NPD6240 | 3 | 102.09 (1.80) | 87.73 (3.81) | 58.21 (2.30) | 26.82 (0.75) |
FSL0005 | 3 | 91.90 (0.78) | 80.91 (2.02) | 103.92 (1.25) | 92.29 (3.01) |
NPD10504 | 4 | 4.22 (1.25) | 106.07 (5.30) | 79.51 (1.51) | 74.57 (1.35) |
NPD3577 | 4 | 36.82 (2.15) | 115.11 (4.34) | 65.54 (2.59) | 81.06 (2.34) |
NPD6303 | 4 | 12.74 (0.64) | 101.47 (3.95) | 78.10 (1.39) | 83.07 (1.76) |
NPD8790 | 4 | 5.34 (1.47) | 99.71 (4.32) | 63.54 (0.90) | 79.84 (1.34) |
Anacardic acid | 5 | 92.95 (1.67) | 87.62 (1.34) | 0.00 (0.00) | 15.80 (1.15) |
NPD390 | 6 | 18.50 (0.92) | 82.90 (1.87) | 85.20 (1.85) | 92.13 (2.10) |
NPL50654-01 | 7 | 0.51 (0.26) | 82.64 (3.27) | 34.10 (0.32) | 22.84 (1.17) |
