Table 3 In vivo activity of NPD8790 analogs against H. polygyrus

From: Identification of a family of species-selective complex I inhibitors as potential anthelmintics

Treatment

Class

Dose (mg/kg)

# Mice cured/ # Mice investigated

Median # of living H. polygyrus worms

% Worm burden reduction

Control

–

–

0/4

124.0 (6.0)

–

NPD8790

A

200

0/4

95.5 (4.0)

23.0

STK951902

A

200

0/4

73.0 (1.5)

41.1

7925515

C

200

0/4

100.0 (8.0)

19.4

7732524

C

200

0/4

93.5 (5.0)

24.6

  1. Worm burdens of mice infected with H. polygyrus were assessed 1 week after a single oral dose of 200 mg/kg of one of four different NPD8790 analogs (NPD8790, STK951902, 925515, 7732524). The median number and median absolute deviation (MAD) of H. polygyrus adults collected from intestine are reported for three to four mice in each drug treatment. Percent reduction in worm burden was calculated by comparing the median worm counts between control and NPD8790 analog-treated mice. Data are one biological replicate of four mice (technical replicates). “–“ indicate values that were not determined.
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