Fig. 2: Diversity, overlap and mass distribution of ACPA IgG1 repertoires determined for a cohort of RA patients (n = 8). | Nature Communications

Fig. 2: Diversity, overlap and mass distribution of ACPA IgG1 repertoires determined for a cohort of RA patients (n = 8).

From: Antigen-specific Fab profiling achieves molecular-resolution analysis of human autoantibody repertoires in rheumatoid arthritis

Fig. 2

a Diversity of ACPA IgG1 repertoires observed within each patient and relative contribution of the ten most abundant Fab molecules to the total ACPA IgG1 repertoires detected. The total number of unique Fab molecules detected is depicted in the center of each donut plot. Each of the ten most abundant Fab molecules is indicated by a separate color; the remaining Fab molecules are indicated in grey. b Overlap between all ACPA IgG1 Fab profiles assessed. The degree of overlap is based on the number and abundance of overlapping Fab molecules and indicated by color gradient. c Exemplary ACPA IgG1 Fab profiles collected for two RA patients. Unique Fab molecules are depicted as peak at their mass. The height of the peak corresponds to the concentration of the respective Fab molecule.

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