Fig. 3: Comparison of ACPA IgG1 versus total plasma IgG1 repertoires. | Nature Communications

Fig. 3: Comparison of ACPA IgG1 versus total plasma IgG1 repertoires.

From: Antigen-specific Fab profiling achieves molecular-resolution analysis of human autoantibody repertoires in rheumatoid arthritis

Fig. 3

a Cumulative percentage of total plasma IgG1 (grey) and ACPA IgG1 repertoires (blue) detected with increasing mass for n = 8 RA patients. Cumulative percentages are determined by summing the relative abundances of Fab molecules detected. b Exemplary total plasma IgG1 (top, grey) and ACPA IgG1 (bottom, blue) Fab profile obtained for patient 4. Note: the 16-fold difference in the y-axis clearly reveals that ACPA IgG1 is a lower abundant sub-repertoire of total plasma IgG1.

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