Fig. 5: In-depth molecular insights into the autoantibody response underlying RA. | Nature Communications

Fig. 5: In-depth molecular insights into the autoantibody response underlying RA.

From: Antigen-specific Fab profiling achieves molecular-resolution analysis of human autoantibody repertoires in rheumatoid arthritis

Fig. 5

ACPA IgG1 repertoires are a low-abundant sub-repertoire of total plasma IgG1 which can be revealed by antigen-specific ACPA IgG1 Fab profiling. The ACPA IgG1 repertoire is found to be diverse, unique to each patient and dominated by a few clones. Compared to plasma IgG1, ACPA IgG1 is extensively glycosylated with an expanded fraction harboring two or more glycans per Fab fragment. Moreover, different glycovariants of the same ACPA clone can be detected.

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