Fig. 3: Condensation is conserved across species and tuned to their respective thermal niches.
From: An adaptive biomolecular condensation response is conserved across environmentally divergent species
a Proportion in the supernatant (pSup) at basal temperature and after heat shock, at species-specific temperatures, across three fungal species. S. cerevisiae data are from Wallace et al. 2015. Top, all detected proteins, with important previously identified classes of proteins highlighted, inferred by orthology from S. cerevisiae. Bottom, summary statistics (mean +/− standard error) for the highlighted classes (for S. kudriavzevii, S. cerevisiae, and K. marxianus respectively, class sizes are: chaperone n = 18, 25, 22; glycolytic n = 11, 16, 18; heat-shock granule n = 19, 21, 20; membrane n = 193, 150, 221; nucleolar n = 236, 217, 255; ribosome n = 69, 103, 108; superaggregator n = 15, 17, 15). b Conservation of condensation across classes of proteins is revealed by correlations between their condensation behaviors within and between species. Left, specific comparisons of basal and shocked condensation between S. kudriavzevii and K. marxianus at their respective optimal growth and shock temperatures; lines connect to their respective entries in the full correlation matrix (showing R2 values), right. Crosses show mean +/− standard error. c Tuning of condensation is revealed by comparison of non-condensing glycolytic proteins and strongly condensing superaggregators across species. Error bars represent the mean +/− standard error. Source data are provided as a Source Data file.
