Fig. 5: Speed-inhibited cells are overrepresented in dHPC→NAc neurons.
From: A hippocampus-accumbens code guides goal-directed appetitive behavior
a–d Speed-excited dHPC neurons. a, b Representative example of one speed-excited neuron. a Sample traces of velocity, position and one neuron’s denoised calcium activity. Note the increased calcium activity in times of high velocity, irrespective of position. b, Linear regression on average calcium events per velocity bin shows a significant positive relationship (slope = 7.43 × 10−4, intercept = −2.097×10−3, r = 0.937, P = 0.0058, n = 18,000 time points). c Heatmaps of speed-binned normalized calcium activity of all significantly positively speed-modulated dHPC- (top) and dHPC→NAc (bottom) neurons. d Proportions of speed-excited neurons are comparable between dHPC- and dHPC→NAc populations (χ²(1, 5372) = 2.565, P = 0.109, chi-squared test). e–h Speed-inhibited dHPC neurons. e, f Representative example of one speed-inhibited neuron. e Sample traces of velocity, position and one neuron’s denoised calcium activity. Note the increased calcium activity in times of low velocity, irrespective of position. f Linear regression on average calcium events per velocity bin shows a significant negative relationship (slope = −1.0437 × 10−4, intercept = 2.814 × 10−3, r = −0.933, P = 0.0065, n = 18,000 time points). g Heatmaps of speed-binned normalized calcium activity of all significantly negatively speed-modulated dHPC- (top) and dHPC→NAc (bottom) neurons. h Negatively tuned neurons are overrepresented in the NAc-projecting population (χ²(1, 5372) = 13.66, P = 0.00022, chi-squared test). Speed-modulated neurons were classified as showing a significant linear regression at P < 0.05 after Benjamini/Hochberg FDR correction. All data are presented as mean ± SEM. ns: not significant, ***P < 0.001. Source data are provided as a Source Data file.
