Table 5 Significant enrichment in biological pathways

From: Fine-mapping analysis including over 254,000 East Asian and European descendants identifies 136 putative colorectal cancer susceptibility genes

Pathwaysa

Genesb

TGF-beta signaling

BAMBI, BMP2, BMP4, BMP7, CDH1, CDKN2B, GREM1, MYC, RUNX2, SMAD3, SMAD6, SMAD7, SMAD9, TGIF1

Hippo signaling

BMP2, BMP4, BMP7, CDH1, GNAS, MYC, PARD6B, SMAD3, SMAD7, TCF7L2, WNT4, WNT7B

TNF-alpha Signaling via NF-kB

TGIF1, BMP2, CDKN1A, EDN1, CEBPB, SMAD3, MYC, IRS2

BMP signaling

BMP2, SMAD6, RUNX2, SMAD9, SMAD7

Pluripotency of stem cells

POU5F1B, BMP4, SMAD3, MYC, WNT7B, SMAD9, TBX3, WNT4, PDGFB, SMAD6, SMAD7, TCF7L2

Epithelial–mesenchymal transition

SMAD3, CDH1, RUNX2, GREM1, COL4A2, LRP1, IGFBP3, LAMC1, NID2, WNT7B, WNT4

Extracellular matrix organization

BMP4, BMP2, COL4A2, PDGFB, NTN4, LAMC1, HSPG2, NID2, BMP7, ADAMTS9

Senescence and Autophagy

BMP2, CDKN1A, CEBPB, SMAD3, MAP1LC3A, IGFBP3, CDKN2B, MYC, KLF5

DNA damage response

TCF7L2, CDKN1A, SMAD3, MYC, WNT7B, WNT4

Cell cycle

CDKN1A, CDKN2B, SMAD3, MYC

Focal adhesion

COL4A2, PDGFB, LAMC1, MYL12A, MYL12B, VAV2

Adherens junction

PTPN1, TCF7L2, SMAD3, CDH1

Glycolysis

GOT1, IGFBP3, IRS2, SOX9, PYGL, LCT

Proteoglycans in cancer

CDKN1A, MYC, WNT7B, HSPG2, WNT4, VAV2

Androgen Response

HPGD, ZMIZ1, STK39, MYL12A

Sphingolipid Metabolism

UGT8, CERS5

Other cancer related pathwaysc

TCF7L2, CDKN1A, EDN1, CDKN2B, SMAD3, WNT7B, PTGER3, PDGFB, LAMC1, MLH1, BMP4, BMP2, COL4A2, TERT, CDH1, MYC, GNA12, GNAS, WNT4, ATF1, CEBPB, BCL11B, HPGD, IGFBP3, RUNX2, ZMIZ1, SMAD6, SMAD7, VAV2, TFEB

  1. aGenes from the same or similar pathway item in multiple databases were combined.
  2. bGenes identified in this study for each pathway item are highlighted in bold.
  3. cGenes from all general cancer-related pathways (i.e., pathway in cancer, colorectal cancer) identified in multiple databases were combined.
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