Fig. 7: Association of drug-mediated transcriptional changes and expression profiles present in human NSCLCs of residual disease.

a Concordance score for the correlation of transcriptional scRNAseq profile at the RD timepoint and LINCS L1000 data⁴⁴ collected for drug-mediated expression changes. Schematic of data processing (top) as well as distribution of concordance scores (bottom) are presented. Sigmoidal distribution of concordance scores across drug perturbations showing significant correlation with residual disease-associated expression changes (n =10,917). Top 50 negative concordance scores are presented in detail, with inhibitors targeting relevant proteins for focal adhesion / SRC or inflammatory signaling highlighted in red and annotated. A schematic diagram was created with BioRender.com. b Pathway schematic for relevant changes in drug-tolerant persister cells, highlighting mechanistic nodes of FAK-YAP-mediated transcriptional adaptation and therapeutic vulnerabilities. A schematic diagram was created with BioRender.com.