Fig. 4: B cells and tertiary lymphoid structures in immune checkpoint blockade (ICB) resistant melanoma.
From: Molecular patterns of resistance to immune checkpoint blockade in melanoma
A Boxplot of fractions of CD20 + B cells by treatment using multiplex immunofluorescence. P-value from Wilcoxon test. Test was two-sided. Green - ICB naïve (n = 52), orange - anti-CTLA4 resistant (CTLA4res) (n = 10), red - anti-PD1 resistant (PD1res) (n = 8), purple - anti-PD1 resistant under BRAFi (PD1res*) (n = 6). Boxplot is displayed with the center-line as median, the box limits as lower and upper quartiles, and with whiskers covering the most extreme values within 1.5 x Interquartile-Range. B–D Multiplex immunofluorescence images of TLSs and B cells in ICB naïve (B), CTLA4res (C) and PD1res (D) melanoma. Representative images are shown. Source data are provided as a Source Data file.
