Fig. 2: Egocentric social-vector cells represent mouse identity.
From: Multiplexed representation of others in the hippocampal CA1 subfield of female mice
a Diagram of the experimental paradigm. An imaged mouse (blue) interacted freely with two social partners (orange and green). Scale bar: 10 cm. b Representative example of the spatial organization of cells classified as egoSVC (dark purple) for each mouse and for both (dark edge). c Representative examples (organized as in Fig. 1e) of cells classified as egoSVC (asterisk) for one or both mice. Scale bar: 20 cm. d Venn diagram of cells classified as egoSVC for each mouse (281 cells out of 897 recorded from 7 mice; overlap index: 1.7, two-tailed Binomial test, p = 8.9 × 10−4). e Distribution across sessions of mean spatial information content of cells classified as egoSVC for each mouse (n (mouse one) = 219 sessions, n (mouse two) = 106 sessions, median ± i.q.r., two-tailed Mann–Whitney test, Mann–Whitney U = 11267, Cliff’s Delta = 0.03, p = 0.67). f Cumulative distribution of correlation between maps corresponding to the first and second halves of a session. For each half of the session, maps were constructed using the relative position of the same (blue) or a different mouse (pink and gray), for cells that were classified as egoSVC for both mice (pink) or only one mouse (gray) (Kruskal–Wallis test, H = 254.1, p = 6.8 × 10−56; Dunn’s multiple comparisons test, all p < 0.002). g Cross-validated error obtained when decoding the relative position of a mouse with a decoder trained with data corresponding to the same (pink) or the other (blue) mouse, together with the shuffled distribution (gray) (one dot per session, mean ± s.e.m., 55 sessions; two-tailed Wilcoxon matched-pairs signed rank tests for same vs. different mice: W = 648, Cliff’s Delta = −0.12, p = 6.1 × 10−3; two-tailed Mann–Whitney test for different mice vs. shuffle: Mann–Whitney U = 76096, Cliff’s Delta = −0.50, p = 2.1 × 10−10). In box plots, the central line indicates the median, and the bottom and top edges of the box mark the interquartile range. Whiskers extend from −1.5 × i.q.r. to +1.5 × i.q.r. from the closest quartile, where i.q.r. is the interquartile range. Black dots mark outliers. Source data are provided as a Source Data file.
