Fig. 3: Synaptic dopaminergic specificity of C80. | Nature Communications

Fig. 3: Synaptic dopaminergic specificity of C80.

From: Dopamine signaling enriched striatal gene set predicts striatal dopamine synthesis and physiological activity in vivo

Fig. 3

a, b Gene ontology (cellular compartment) and KEGG enrichment of C80 for both pre and post-synaptic compartments as well as dopaminergic, GABAergic, and glutamatergic synapses. Overrepresentation analysis was performed using the clusterProfiler R116 package and FDR-adjusted p-values are reported. Diamonds represent fold enrichment (x-axis) for each Gene ontology category (y-axis) and are colored based on the respective adjusted p-value. c Venn Diagram shows the intersection between C80 genes and genes expressed in subpopulations of D1- and D2-expressing MSNs in the nucleus accumbens as defined by Tran, Maynard40. A larger intersection is found with D2-MSN than D1-MSN. d Overlap between SDA components generated from the LIBD and GTEx datasets that are significantly replicated (one-sided permutation test; empirical p-value < 0.001) using JI or gene loading correlation. Discovery C80 and replication C18 are one of the 4 pairs of components consistent with both JI and gene loading. JI jaccard index, MSN medium spiny neurons.

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