Fig. 3: Signatures of COVID-19 response seven days after symptoms onset. | Nature Communications

Fig. 3: Signatures of COVID-19 response seven days after symptoms onset.

From: Multi-omics analysis reveals COVID-19 vaccine induced attenuation of inflammatory responses during breakthrough disease

Fig. 3

a Principal component analysis of blood RNA-seq transcriptome (next-gen RNA seq) of study participants before and around symptomatic episode consistent with COVID-19. The dashed arrows connect the different time points from the same participants; the direction of the arrows is pointing towards the latter time point. D0 n = 10, CT NAAT-ve n = 13, CT NAAT+ve ChAdOx1 nCoV-19 n = 7, CT NAAT+ve placebo n = 9, CT + 7 NAAT-ve n = 7, CT + 7 NAAT+ve ChAdOx1 nCoV-19 n = 5, CT + 7 NAAT+ve placebo n = 7. b GSEA gene ontology biological process at CT + 7 in NAAT+ve placebo vaccinated individuals (n = 7) compared with baseline placebo samples (n = 10). c GSEA gene ontology biological process at CT + 7 NAAT+ve (ChAdOx1 nCoV-19) individuals (n = 5) compared with baseline (D0) samples (n = 10). d Volcano plot comparing the small RNA-seq blood transcriptome at CT + 7 in NAAT+ve placebo vaccinated individuals (n = 7) compared with baseline (D0) samples (n = 10). Blue = downregulated at CT + 7 (FDR < 0.05), red = upregulated at CT + 7(FDR < 0.05). The top 20 differentially expressed genes — ranked by FDR— are labelled, with the omission of overlapping labels. Differential expression analysis was performed using a two-sided moderate t-test. Source data are provided as a Source Data file.

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