Fig. 2: In vivo immunogenicity of CoPoP HIV-1 Env particles in NZW rabbits. | Nature Communications

Fig. 2: In vivo immunogenicity of CoPoP HIV-1 Env particles in NZW rabbits.

From: CoPoP liposomes displaying stabilized clade C HIV-1 Env elicit tier 2 multiclade neutralization in rabbits

Fig. 2

a Schematic of study design with details on immunization schedule of rabbits receiving the different Env-CoPoP immunogens adjuvanted with Adjuplex along with the control group receiving buffer. b Direct ELISA titers of immunized rabbits at week 18 against the ConC gp140 trimer to detect total binding antibodies. c Capture ELISA titers of immunized rabbits at week 18 against the ConC gp140 trimer to detect antibodies binding to conformational epitopes. d ELISA titers of immunized rabbits at week 18 against the His-tag to assess off-target anti-His responses indicating Env detachment. Bars in b–d represent median with 95% confidence interval (CI) for individual rabbits within the Env-CoP1 (N = 9), Env-CoP2 (N = 9), Env-CoP3 (N = 8) and control (N = 4) groups; and the dotted lines represent the ELISA assay lower limit of detection (LLOD). Numbers at the bottom of the graphs b–d denote median values. Source data are provided as a Source Data file.

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